Preparation and <i>in Vitro</i> Evaluation of Tamoxifen-Conjugated, Eco-Friendly, Agar-Based Hybrid Magnetic Nanoparticles for Their Potential Use in Breast Cancer Treatment

Tamoxifen is the drug of choice as hormonal therapy for hormone receptor-positive breast cancers and can reduce risk cancer recurrence. However, oral tamoxifen has a low bioavailability due to liver intestinal metabolic passes. To overcome this problem utilize potential its maximum, inorganic nanoparticle carriers have been exploited tested increase bioavailability. Biocompatibility unique magnetic properties make iron oxide nanoparticles an excellent delivery system. In study, we developed “green synthesis” approach synthesize from green tea extract coated them with agar longer stability (AG-INPs). Later, these hybrid were conjugated (TMX). By using approach, synthesized stable agar-coated tamoxifen-conjugated (TMX-AG-INPs) characterized Fourier-transform infrared (FTIR) spectroscopy. The average particle size AG-INPs was 26.8 nm, while tamoxifen-loaded nanoparticles, TMX-AG-INPs, 32.1 measured by transmission scanning electron microscopy. entrapment efficiency TMX-AG-INPs obtained release profile 88%, loading capacity 43.5%. significantly (p < 0.001) efficient in killing cells when vitro on established cell line MCF-7 viability assay, indicating their control proliferation.